The unit of Translational Research in Oncology (UTRiO) is headed by prof. Dr. Steven Goossens and currently consists of two technicians, five PhD students and one postdoctoral researcher. In our unit, we aim to get a better understanding of cancer initiation and progression on the molecular level. Starting from a clinical need and patient samples, we create genetic models, in vitro patient-derived primary cultures and in vivo PDX models. Using these models, we search for novel oncogenic drivers and tumor suppressors and identify specific biomarkers to develop improved, specific cancer therapies causing less side effects. These biomarkers in combination with specific drugs allow personalized medicine and treatment of smaller patient groups targeting aggressive subtypes of cancer.